Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

EXO5 / Exonuclease 5

exonuclease 5

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.

Gene Name: exonuclease 5
Synonyms: EXO5, C1orf176, DEM1, Exo V, Exonuclease 5
Target Sequences: NM_022774 NP_073611.1 Q9H790

Publications (1)

1
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Shashank Hambarde, Chi-Lin Tsai, Raj K Pandita, Albino Bacolla, Anirban Maitra, Vijay Charaka, Clayton R Hunt, Rakesh Kumar, Oliver Limbo, Remy Le Meur, Walter J Chazin, Susan E Tsutakawa, Paul Russell, Katharina Schlacher, Tej K Pandita, John A Tainer. Molecular cell. 2021 July;81:2989-3006.e9. [Full Text Article] [PubMed:34197737] [PMC:PMC8720176] Related Antibodies: LS-C410042.

☰ Filters
Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
EXO5 / Exonuclease 5 (4)
No (4)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
EXO5 / Exonuclease 5 Protein - Purified recombinant protein EXO5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
41.6 kDa
20 µg/$1,107
EXO5 / Exonuclease 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.6 kDa
20 µg/$150
EXO5 / Exonuclease 5 Protein
Select
E. coli
His-SUMO
57.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
EXO5 / Exonuclease 5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.6 kDa
100 µg/$494
Viewing 1-4 of 4 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).