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EXO5 / Exonuclease 5

exonuclease 5

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.

Gene Name: exonuclease 5
Synonyms: EXO5, C1orf176, DEM1, Exo V, Exonuclease 5
Target Sequences: NM_022774 NP_073611.1 Q9H790

Publications (1)

1
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Shashank Hambarde, Chi-Lin Tsai, Raj K Pandita, Albino Bacolla, Anirban Maitra, Vijay Charaka, Clayton R Hunt, Rakesh Kumar, Oliver Limbo, Remy Le Meur, Walter J Chazin, Susan E Tsutakawa, Paul Russell, Katharina Schlacher, Tej K Pandita, John A Tainer. Molecular cell. 2021 July;81:2989-3006.e9. [Full Text Article] [PubMed:34197737] [PMC:PMC8720176] Related Antibodies: LS-C410042.

☰ Filters
Products
Antibodies (12)
Primary (12)
EXO5 / Exonuclease 5 (12)
Human (12)
Mouse (8)
Bat (3)
Chimpanzee (3)
Gibbon (3)
Hamster (7)
Monkey (3)
Orangutan (3)
Rabbit (3)
WB (12)
Flo (7)
ELISA (6)
rabbit (12)
IgG (7)
polyclonal pc (12)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (4)
aa166-193 (7)
aa202-251 (4)
No (11)
Yes (1)
EXO5 / Exonuclease 5 Antibody - Western blot analysis of extracts of various cells.
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
EXO5 / Exonuclease 5 Antibody - DEM1 Antibody western blot of MDA-MB435 cell line lysates (35 ug/lane). The DEM1 antibody detected the DEM1 protein (arrow).
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) Antibody
Mouse, Hamster, Human
Flo, WB
Unconjugated
400 µl/$393
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) (Biotin) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) (FITC) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) (APC) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) (Azide-free) (HRP) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa166-193) (PE) Antibody
Mouse, Hamster, Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
EXO5 / Exonuclease 5 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa202-251) Antibody
Human
WB
Unconjugated
100 µl/$424
EXO5 / Exonuclease 5 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa202-251) (HRP) Antibody
Rabbit, Bat, Gibbon, Human, Monkey, Chimpanzee, Orangutan
WB
HRP Conjugated
100 µl/$469
EXO5 / Exonuclease 5 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa202-251) (Biotin) Antibody
Rabbit, Bat, Gibbon, Human, Monkey, Chimpanzee, Orangutan
WB
Biotin Conjugated
100 µl/$469
EXO5 / Exonuclease 5 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
EXO5 / Exonuclease 5 Rabbit anti-Human Polyclonal (aa202-251) (FITC) Antibody
Rabbit, Bat, Gibbon, Human, Monkey, Chimpanzee, Orangutan
WB
FITC Conjugated
100 µl/$469
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).