ETHE1

ethylmalonic encephalopathy 1

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H2S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H2S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

ETHE1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human ETHE1 Protein (Recombinant His) - LS-G1601

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human ETHE1 Protein (Recombinant His-SUMO) (aa8-254) - LS-G20715

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

43.08 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ETHE1 Protein (Recombinant GST) (Full Length) - LS-G32855

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ETHE1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69921

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.7 kDa

Price:

20 µg/$1,107

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Human ETHE1 Protein (Recombinant GST, N-terminus) (aa155-254) - LS-G62010

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ETHE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85854

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.7 kDa

Price:

20 µg/$150

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ETHE1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101190

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.7 kDa

Price:

100 µg/$494

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