ESRRG / ERR Gamma

estrogen-related receptor gamma

ESRRG / ERR Gamma is a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.

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Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

ESRRG / ERR Gamma (10)

Publications

No (10)

Tag

GST (2)

Myc-DDK (Flag) (8)

Species

Human (8)

Source

293T Cells (2)

HEK 293 Cells (6)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human ESRRG / ERR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67021

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.1 kDa

Price:

20 µg/$1,107

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Human ESRRG / ERR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67022

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$1,107

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Human ESRRG / ERR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67023

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$1,107

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Human ESRRG / ERR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67024

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$1,107

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Human ESRRG / ERR Gamma Protein (Recombinant GST) (Full Length) - LS-G28393

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ESRRG / ERR Gamma Protein (Recombinant GST) (Full Length) - LS-G28392

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74.36 kDa

Price:

2 µg/$439

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ESRRG / ERR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102996

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

100 µg/$710

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ESRRG / ERR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99441

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.1 kDa

Price:

100 µg/$710

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Human ESRRG / ERR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78955

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.1 kDa

Price:

20 µg/$215

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Human ESRRG / ERR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78957

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$215

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