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ESRP1 / RBM35A
epithelial splicing regulatory protein 1
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
| Gene Name: | epithelial splicing regulatory protein 1 |
| Synonyms: | ESRP1, RBM35A, RMB35A, RNA binding motif protein 35A, RNA-binding motif protein 35A, RNA-binding protein 35A |
| Target Sequences: | NM_017697 NP_060167.2 Q6NXG1 |
Publications (1)
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