ESET / SETDB1

SET domain, bifurcated 1

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

ESET / SETDB1 (9)

Publications

No (9)

Tag

GST, N-terminus (3)

Myc-DDK (Flag) (6)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ESET / SETDB1 Protein (Recombinant GST, N-terminus) (aa1-397) - LS-G57552

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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ESET / SETDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126701

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143 kDa

Price:

100 µg/$710

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Human ESET / SETDB1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66140

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143 kDa

Price:

20 µg/$1,107

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Human ESET / SETDB1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66141

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

142.8 kDa

Price:

20 µg/$1,107

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Human ESET / SETDB1 Protein (Recombinant GST, N-terminus) (aa2-100) - LS-G61268

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ESET / SETDB1 Protein (Recombinant GST, N-terminus) (aa247-348) - LS-G61272

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ESET / SETDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77013

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143 kDa

Price:

20 µg/$215

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Human ESET / SETDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77015

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

142.8 kDa

Price:

20 µg/$150

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ESET / SETDB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101096

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

142.8 kDa

Price:

100 µg/$494

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