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ESE3 / EHF
ets homologous factor
Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
| Gene Name: | ets homologous factor |
| Synonyms: | EHF, ESE3, ESE3B, ESE-3, ESE3 transcription factor, Ets homologous factor, ESEJ, HEHF |
| Target Sequences: | NM_012153 NP_036285.2 Q9NZC4 |
Publications (1)
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