ERBB4 / HER4

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

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Proteins (16)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (4)

Recombinant (11)

Target

ERBB4 / HER4 (16)

Publications

No (16)

Tag

6His, N-terminus (1)

Fc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His, C-Terminal (1)

His,C-terminus (1)

His-T7 (1)

Human IgG1 Fc (1)

Myc-DDK (Flag) (5)

Species

Human (11)

Mouse (1)

Rat (2)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (5)

Human (1)

Human Cells (4)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (7)

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Human ERBB4 / HER4 Protein (Recombinant Human IgG1 Fc) (Met1-Arg649) - LS-G97434

Source:

Human Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

96.6 kDa

Price:

100 µg/$721

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Human ERBB4 / HER4 Protein (Recombinant His,C-terminus) (Gln26-Arg649) - LS-G139227

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.5 kDa

Price:

10 µg/$277; 50 µg/$389

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ERBB4 / HER4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119605

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

145.2 kDa

Price:

100 µg/$710

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Human ERBB4 / HER4 Protein (Recombinant His-T7) (aa29-278) - LS-G24674

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.0 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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Human ERBB4 / HER4 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ser27-Val1308) - LS-G26875

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

150 kDa

Price:

200 µl/$283

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Human ERBB4 / HER4 Protein (Recombinant GST) (Full Length) - LS-G28376

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

169.51 kDa

Price:

2 µg/$439

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Human ERBB4 / HER4 Protein (Recombinant GST, N-terminus) (aa26-125) - LS-G58479

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ERBB4 / HER4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67972

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

142.6 kDa

Price:

20 µg/$1,107

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Human ERBB4 / HER4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81117

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

146.81 kDa

Price:

20 µg/$215

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Human ERBB4 / HER4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81118

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

145.2 kDa

Price:

20 µg/$215

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ERBB4 / HER4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100487

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

146.81 kDa

Price:

100 µg/$710

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Human ERBB4 / HER4 Protein (Recombinant His) (Met1-Arg649) - LS-G97433

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.1 kDa

Price:

100 µg/$721

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Rat ERBB4 / HER4 Protein (Recombinant Fc, C-terminus) (Met1-Pro651) - LS-G138218

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

96.9 kDa

Price:

100 µg/$721

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Human ERBB4 / HER4 Protein (Recombinant His, C-Terminal) (Gln26-Arg649) - LS-G55750

Source:

Human

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.5kD

Price:

50 µg/$395; 500 µg/$1,262; 1 mg/$1,627; 10 µg/$277

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Mouse ERBB4 / HER4 Protein (Recombinant His) (Met1-Leu652) - LS-G98138

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.5 kDa

Price:

100 µg/$721

Select

Rat ERBB4 / HER4 Protein (Recombinant His) (Met1-Pro651) - LS-G98389

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.3 kDa

Price:

100 µg/$721

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