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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ERBB4 / HER4

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.

Gene Name: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Family/Subfamily: Protein Kinase , EGF Receptor
Synonyms: ERBB4, ERBB 4, HER4, p180 erb4, p180erbB4
Target Sequences: NM_005235 NP_005226.1 Q15303

Publications (1)

1
Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer. Roßner F, Gieseler C, Morkel M, Royer HD, Rivera M, Bläker H, Dietel M, Schäfer R, Sers C. Oncogenesis. 2016 5:e187. (IHC, WB; Human) [Full Text Article] [PubMed:26779809] [PMC:PMC4728680] Related Antibodies: LS-C97506.

Filtered by: None
Type
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Recombinant (13)
Target
ERBB4 / HER4 (18)
Tag
6His,N-terminus (1)
GST (1)
GST,N-terminus (1)
His (4)
His + Fc (1)
His + T7 (1)
His, C-Terminal (1)
Human IgG1 Fc (1)
Myc + DDK (5)
Species
Human (14)
Mouse (1)
Rat (1)
Source
293T Cells (2)
E. coli (1)
HEK 293 Cells (5)
Human (1)
Human Cells (6)
Insect Cells (1)
Wheat Germ Extract (2)
Purification
Purified (9)
Low Endotoxin Level
Low endotoxin level (8)
Biologically Active
Biologically active (3)
Publications
No (18)
Showing 1-18 of 18 results

Human ERBB4 / HER4 Protein (Recombinant Human IgG1 Fc) (Met1-Arg649) - LS-G97434
Human Cells
Human IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
96.6 kDa
50µg  $485.00; 100µg  $815.00

Human ERBB4 / HER4 Protein (Recombinant GST,N-terminus) (aa26-125) - LS-G58479
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human ERBB4 / HER4 Protein (Over-Expression Cell Culture Supernatant 6His,N-terminus) (Ser27-Val1308) - LS-G26875
HEK 293 Cells
6His,N-terminus
150 kDa
200µl  $235.00

Human ERBB4 / HER4 Protein (Recombinant) - LS-G131749
Insect Cells
None
Biologically active
~57 kDa
10µg  $365.00

Human ERBB4 / HER4 Protein (Recombinant His + T7) (aa29-278) - LS-G24674
E. coli
His + T7
32.0 kDa
10µg  $285.00; 50µg  $485.00; 100µg  $650.00; 200µg  $965.00; 1mg  $2,460.00; 500µg  $1,095.00
Recombinant  V-Erb A Erythroblastic Leukemia Viral Oncogene Homolog 4 By SDS-PAGE

Human ERBB4 / HER4 Protein (Recombinant GST) (Full Length) - LS-G28376
Wheat Germ Extract
GST
169.51 kDa
2µg  $385.00
12.5% SDS-PAGE of human ERBB4 stained with Coomassie Blue

Human ERBB4 / HER4 Protein (Recombinant) - LS-G5492
Human Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
975 kDa
5µg  $355.00

Human ERBB4 / HER4 Protein (Recombinant His) - LS-G5191
HEK 293 Cells
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
70.6 kDa. Protein migrates as 95-110 kDa in reduced SDS-PAGE due to glycosylation
50µg  $890.00; 10µg  $345.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human ERBB4 / HER4 Protein (Recombinant His, C-Terminal) (Gln26-Arg649) - LS-G55750
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
70.5kD
50µg  $335.00; 500µg  $1,170.00; 1mg  $1,680.00; 10µg  $225.00

Human ERBB4 / HER4 Protein (Recombinant Myc + DDK) (Full Length) - LS-G67972
HEK 293 Cells
Myc + DDK
142.6 kDa
20µg  $950.00
Purified recombinant protein ERBB4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human ERBB4 / HER4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G81117
293T Cells
Myc + DDK
146.81 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human ERBB4 / HER4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G81118
293T Cells
Myc + DDK
145.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

ERBB4 / HER4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G119605
HEK 293 Cells
Myc + DDK
145.2 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human ERBB4 / HER4 Protein (Recombinant His) (Met1-Arg649) - LS-G97433
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
71.1 kDa
50µg  $485.00; 100µg  $815.00

Human ERBB4 / HER4 Protein (Recombinant His + Fc) (Met1-Pro651) - LS-G97435
Human Cells
His + Fc
Less than 1.0 EU/µg protein (determined by LAL method).
97.5 kDa
50µg  $485.00; 100µg  $815.00

ERBB4 / HER4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G100487
HEK 293 Cells
Myc + DDK
146.81 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Mouse ERBB4 / HER4 Protein (Recombinant His) (Met1-Leu652) - LS-G98138
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
71.5 kDa
50µg  $485.00; 100µg  $815.00

Rat ERBB4 / HER4 Protein (Recombinant His) (Met1-Pro651) - LS-G98389
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
71.3 kDa
50µg  $485.00; 100µg  $815.00
Showing 1-18 of 18 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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