ERBB3 / HER3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

ERBB3 / HER3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

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Products

ELISA Kits (12)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (4)

Sandwich (5)

Target

ERBB3 / HER3 (12)

Reactivity

Human (9)

Mouse (4)

Rat (3)

Format

96-Well Microplate (4)

96-Well Strip Plate (8)

Publications

No (12)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (3)

Cell Lysates (1)

Plasma (6)

Serum (6)

Tissue Homogenates (2)

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Mouse/Human/Rat Phospho-ERBB3 / HER3 (Tyr1197) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1749

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human Phospho-ERBB3 / HER3 (Tyr1222) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1364

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat ERBB3 / HER3 (Cell-Based ELISA) ELISA Kit - LS-F2047

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human ERBB3 / HER3 (Sandwich ELISA) ELISA Kit - LS-F31640

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

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Mouse ERBB3 / HER3 (Custom ELISA) ELISA Kit - LS-F20383

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat ERBB3 / HER3 (Custom ELISA) ELISA Kit - LS-F20384

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ERBB3 / HER3 (Custom ELISA) ELISA Kit - LS-F20385

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$685

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Human ERBB3 / HER3 (Sandwich ELISA) ELISA Kit - LS-F39718

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$795

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Human ERBB3 / HER3 (Custom ELISA) ELISA Kit - LS-F56795

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Mouse ERBB3 / HER3 (Sandwich ELISA) ELISA Kit - LS-F8703

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

7.81 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$854

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Human ERBB3 / HER3 (Sandwich ELISA) ELISA Kit - LS-F9464

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Human ERBB3 / HER3 (Sandwich ELISA) ELISA Kit - LS-F78

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

3.43 - 833.3 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$588

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