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ERBB2IP / Erbin

erbb2 interacting protein

ERBB2IP / Erbin is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name:	erbb2 interacting protein
Synonyms:	ERBB2IP, Erbb2-interacting protein, ERBIN, Erbb2 interacting protein, KIAA1225, Protein LAP2, LAP2, Densin-180-like protein
Target Sequences:	NM_018695 NP_061165.1 Q96RT1

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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