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ER81 / ETV1

ets variant 1

ER81 / ETV1 is a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: ets variant 1
Synonyms: ETV1, Ets-related protein 81, ER81, Ets variant 1, ETS translocation variant 1, Ets variant gene 1
Target Sequences: NM_004956 NP_004947.2 P50549

Publications (1)

1
Androgen up-regulation of Twist1 gene expression is mediated by ETV1. Prabesh Khatiwada , Archana Kannan , Mamata Malla, Megan Dreier, Lirim Shemshedini. PeerJ. 2020 Apr;8:e8921. [Full Text Article] [PubMed:32296610] [PMC:PMC7151753] Related Antibodies: LS-C352170.

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Proteins (12)
Over-Expression Lysate (10)
Recombinant (2)
ER81 / ETV1 (12)
No (12)
GST, N-terminus (1)
Myc-DDK (Flag) (11)
Human (7)
293T Cells (5)
HEK 293 Cells (6)
Wheat Germ Extract (1)
ER81 / ETV1 Protein - Purified recombinant protein ETV1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55 kDa
20 µg/$1,107
ER81 / ETV1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
50 kDa
20 µg/$150
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.3 kDa
20 µg/$150
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48 kDa
20 µg/$150
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.3 kDa
20 µg/$150
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
55 kDa
20 µg/$150
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
55 kDa
100 µg/$494
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.3 kDa
100 µg/$494
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
48 kDa
100 µg/$494
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
50 kDa
100 µg/$494
ER81 / ETV1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
52.3 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).