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EPS15L1 / EPS15R

epidermal growth factor receptor pathway substrate 15-like 1

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene Name:	epidermal growth factor receptor pathway substrate 15-like 1
Synonyms:	EPS15L1, Eps15-related protein, EPS15R
Target Sequences:	NM_021235 NP_067058.1 Q9UBC2

Publications (1)

Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Chen C, Zhuang X. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:11790-5. (ICC) [PubMed:18689690] [PMC:PMC2504482]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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