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EPS15
epidermal growth factor receptor pathway substrate 15
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
| Gene Name: | epidermal growth factor receptor pathway substrate 15 |
| Synonyms: | EPS15, AF-1P, AF1P, MLLT5, Protein AF-1p, Protein Eps15 |
| Target Sequences: | NM_001981 NP_001972.1 P42566 |
Publications (1)
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