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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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EPHB4 / EPH Receptor B4
EPH receptor B4
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
| Gene Name: | EPH receptor B4 |
| Family/Subfamily: | Protein Kinase , Ephrin Receptor |
| Synonyms: | EPHB4, EPH receptor B4, Ephrin receptor EphB4, Ephrin type-B receptor 4, HTK, MYK1, TYRO11, Soluble EPHB4 variant 1, Soluble EPHB4 variant 3, Hepatoma transmembrane kinase, MDK2, Soluble EPHB4 variant 2, Tyrosine-protein kinase TYRO11 |
| Target Sequences: | NM_004444 NP_004435.3 P54760 |
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