EPHB2 / EPH Receptor B2

EPH receptor B2

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

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Products

Proteins (8)

Type

Recombinant (8)

Target

EPHB2 / EPH Receptor B2 (8)

Publications

No (8)

Tag

DDK (Flag)-His, C-terminus (1)

Fc, C-terminus (2)

Fc-His, C-terminus (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Species

Human (8)

Source

Baculovirus (1)

HEK 293 Cells (2)

Human Cells (3)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (6)

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant Fc, C-terminus) (Val19-Ser482) - LS-G40031

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78.5kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant GST, N-terminus) (aa226-325) - LS-G58469

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant His-GST) (Gly570-Val987) - LS-G97421

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75.2 kDa

Price:

50 µg/$707

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant) (Met1-Leu543) - LS-G97422

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59 kDa

Price:

100 µg/$721

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant His) (Met1-Leu543) - LS-G97425

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.7 kDa

Price:

100 µg/$721

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Human EPHB2 / EPH Receptor B2 Protein (Recombinant Fc, C-terminus) (Val19-Ser482) - LS-G139036

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78.5 kDa

Price:

10 µg/$277; 50 µg/$389

Select

Human EPHB2 / EPH Receptor B2 Protein (Recombinant Fc-His, C-terminus) (Met1-Leu543) - LS-G138069

Source:

HEK 293 Cells

Tag:

Fc-His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86 kDa

Price:

100 µg/$721

Select

Human EPHB2 / EPH Receptor B2 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142219

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

61 kDa

Price:

20 µg/$1,107

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