EPHB1 / EPH Receptor B1

EPH receptor B1

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

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Products

Proteins (10)

Type

Recombinant (10)

Target

EPHB1 / EPH Receptor B1 (10)

Publications

No (10)

Tag

6His, C-terminus (1)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (1)

GST, N-terminus (1)

His (1)

His,C-terminus (2)

His/GST,N-terminus (1)

His-GST (1)

Species

Human (8)

Mouse (2)

Source

Baculovirus (1)

HEK 293 Cells (2)

Human (1)

Human Cells (2)

Insect Cells (1)

Mammalian Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (7)

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Mouse EPHB1 / EPH Receptor B1 Protein (Recombinant His,C-terminus) (Met1-Leu539) - LS-G138464

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.6 kDa

Price:

200 µg/$1,148

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant Fc, C-terminus) - LS-G146177

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

85.6 kDa

Price:

10 µg/$377; 50 µg/$774

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Mouse EPHB1 / EPH Receptor B1 Protein (Recombinant His/GST,N-terminus) (Met591-Ala984) - LS-G140016

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.4 kDa

Price:

50 µg/$707

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant DDK,C-terminus) - LS-G142403

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

60.2 kDa

Price:

20 µg/$677

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142218

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

61 kDa

Price:

20 µg/$1,107

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G58467

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant His,C-terminus) (Ser564-Ala984) - LS-G139356

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.8 kDa

Price:

10 µg/$281; 50 µg/$389

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant His) (Met1-Pro540) - LS-G97418

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

60 kDa

Price:

50 µg/$721

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant His-GST) (Arg565-Ala984) - LS-G97420

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75.3 kDa

Price:

50 µg/$707

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Human EPHB1 / EPH Receptor B1 Protein (Recombinant 6His, C-terminus) (Ser564-Ala984) - LS-G39223

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.8kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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