EPHA7 / EPH Receptor A7

EPH receptor A7

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

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ELISA Kits (1)

Type

Cell-Based (1)

Target

EPHA7 / EPH Receptor A7 (1)

Reactivity

Human (1)

Mouse (1)

Rat (1)

Format

96-Well Microplate (1)

Publications

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Sample Type

Adherent Cell Cultures (1)

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Mouse/Human/Rat EPHA7 / EPH Receptor A7 (Cell-Based ELISA) ELISA Kit - LS-F1966

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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