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EPHA3 / EPH Receptor A3

EPH receptor A3

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Gene Name: EPH receptor A3
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHA3, CEK4 kinase, EPH receptor A3, Ephrin type-A receptor 3, Eph-like tyrosine kinase 1, ETK1, HEK4, EPH-like kinase 4, HEK, Human embryo kinase 1, MEK4 kinase, Human embryo kinase, Tyrosine-protein kinase TYRO4, TYRO4, EK4, Eph kinase A3, ETK
Target Sequences: NM_005233 NP_005224.2 P29320

Publications (1)

1
A molecular mechanism for the topographic alignment of convergent neural maps. Savier E, Eglen SJ, Bathélémy A, Perraut M, Pfrieger FW, Lemke G, Reber M. eLife. 2017 March;6:pii: e20470. (Mouse, Human) [Full Text Article] [PubMed:28322188] [PMC:PMC5360444]

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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
EPHA3 / EPH Receptor A3 (13)
No (13)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc (1)
Fc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (3)
His-GST (1)
Myc-DDK (Flag) (3)
Human (7)
Mouse (3)
Rat (2)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (4)
Human Cells (4)
Sf9 Cells (1)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (6)
EPHA3 / EPH Receptor A3 Protein - Purified recombinant protein EPHA3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
110 kDa
20 µg/$1,107
EPHA3 / EPH Receptor A3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
60.3 kDa
100 µg/$721
EPHA3 / EPH Receptor A3 Protein - 12.5% SDS-PAGE of human EPHA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
136.5 kDa
10 µg/$479; 25 µg/$670
EPHA3 / EPH Receptor A3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
110 kDa
100 µg/$494
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
85.7 kDa
200 µg/$1,148
EPHA3 / EPH Receptor A3 Protein
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Sf9 Cells
DDK,C-terminus
58.8 kDa
20 µg/$677
EPHA3 / EPH Receptor A3 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
62 kDa
20 µg/$1,107
EPHA3 / EPH Receptor A3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
110 kDa
20 µg/$150
Select
Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
74.3 kDa
50 µg/$707
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
60.2 kDa
200 µg/$661
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
61.2 kDa
200 µg/$1,148
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
85.8 kDa
200 µg/$1,148
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).