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EPHA3 / EPH Receptor A3
EPH receptor A3
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
| Gene Name: | EPH receptor A3 |
| Family/Subfamily: | Protein Kinase , Ephrin Receptor |
| Synonyms: | EPHA3, CEK4 kinase, EPH receptor A3, Ephrin type-A receptor 3, Eph-like tyrosine kinase 1, ETK1, HEK4, EPH-like kinase 4, HEK, Human embryo kinase 1, MEK4 kinase, Human embryo kinase, Tyrosine-protein kinase TYRO4, TYRO4, EK4, Eph kinase A3, ETK |
| Target Sequences: | NM_005233 NP_005224.2 P29320 |
Publications (1)
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