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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EPHA2 / EPH Receptor A2

EPH receptor A2

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Gene Name: EPH receptor A2
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHA2, CTPA, EPH receptor A2, Ephrin type-A receptor 2, Epithelial cell kinase, ECK, Sek-2, ARCC2, Soluble EPHA2 variant 1, CTPP1
Target Sequences: NM_004431 NP_004422.2 P29317

Filtered by: None
Target
EPHA2 / EPH Receptor A2 (117)
Reactivity
Human (101)
Mouse (71)
Rat (26)
Bovine (10)
Dog (9)
Guinea pig (1)
Hamster (14)
Horse (2)
Monkey (4)
Pig (1)
Rabbit (1)
Application
IHC (19)
IHC-P (6)
WB (100)
Flo (22)
Agon (2)
DB (8)
ELISA (64)
Func (1)
ICC (10)
IF (7)
IP (22)
Peptide-ELISA (4)
Host
rabbit (90)
mouse (24)
human (1)
rat (2)
Isotype
IgG (66)
IgG,k (1)
IgG1 (9)
IgG1,k (8)
IgG2a (1)
IgG2a,k (1)
IgG2b (2)
IgG2b,k (4)
IgM (2)
Clonality
monoclonal mc (26)
polyclonal pc (89)
recombinant monoclonal rmc (2)
Clone
1B3C7 (2)
1C1 (2)
3D7 (1)
6F8 (1)
AT66G9 (1)
D7 (1)
GM5H5 (1)
PAT66G9AT (1)
Format
AP Conjugated (8)
APC Conjugated (9)
Azide-free (4)
Biotin Conjugated (9)
FITC Conjugated (10)
HRP Conjugated (9)
PE Conjugated (11)
Unconjugated (61)
Epitope
aa296-323 (8)
aa30-60 (8)
aa919-950 (8)
pSer897 (8)
pTyr588 (3)
pTyr772 (3)
C-Terminus (2)
Human Ephrin Type A receptor 2 (2)
N-Terminus (2)
aa559-976 (2)
100-180 aa, N-terminal (1)
Extracellular Domain (1)
Internal (1)
aa425-519 (1)
aa450-500 (1)
aa518-552 (1)
aa533-582 (1)
aa729-778 (1)
aa926-976 (1)
aa954-976 (1)
pTyr588,pTyr596 (1)
pTyr594 (1)
Publications
No (117)
Showing 1-25 of 117 results

IHC-plus™ EPHA2 / EPH Receptor A2 Antibody (aa559-976, clone 3D7) LS-B3002
Mouse Monoclonal [clone 3D7] (IgG2b,k) to Human EPHA2 / EPH Receptor A2
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-EPHA2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-EPHA2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ EPHA2 / EPH Receptor A2 Antibody (aa450-500) LS-B1794
Rabbit Polyclonal to Human EPHA2 / EPH Receptor A2
Mouse, Dog, Bovine, Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-EPHA2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of human EphA2 in human ovary lysate in the? absence of immunizing peptide using antibody at 1 ug/ml.

EPHA2 / EPH Receptor A2 Antibody (clone GM5H5) LS-C90394
Mouse Monoclonal [clone GM5H5] (IgG1) to Human EPHA2 / EPH Receptor A2
Human
ELISA, Flo, IF
Unconjugated
100µg 1mg/ml  $575.00

EPHA2 / EPH Receptor A2 Antibody (Extracellular Domain) LS-C36249
Mouse Monoclonal (IgG2a) to Human EPHA2 / EPH Receptor A2
Mouse, Dog, Bovine, Human
Flo, ICC, WB
Unconjugated
100µg  $680.00

EPHA2 / EPH Receptor A2 Antibody (clone D7, PE) LS-C128748
Mouse Monoclonal [clone D7] (IgG1) to Human EPHA2 / EPH Receptor A2
Human
Flo
PE Conjugated
100tst  $665.00

EPHA2 / EPH Receptor A2 Antibody (phospho-Ser897) LS-C163608
Rabbit Polyclonal to Human EPHA2 / EPH Receptor A2
Human
DB, WB
Unconjugated
400µl  $325.00
Western blot of EphA2 Antibody (pS897) antibody (RB21717) pre-incubated without(lane 1) and with(lane 2) FBS in HA cell line lysate. EphA2 Antibody (pS897) (arrow) was detected using the purified antibody(Kindly provided by Dr. John Wu).
Dot blot of anti-phospho-EphA2-pS897 Phospho-specific antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

EPHA2 / EPH Receptor A2 Antibody (aa30-60) LS-C100255
Rabbit Polyclonal to Human EPHA2 / EPH Receptor A2
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of hEPHA2-T45 in MCF-7 cell line lysates (35 ug/lane). EPHA2 (arrow) was detected using the purified Pab

EPHA2 / EPH Receptor A2 Antibody (aa30-60) LS-C327287
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, Biotin) LS-C225344
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl  $740.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, FITC) LS-C225345
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, APC) LS-C225343
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl  $740.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, AP) LS-C225342
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl  $740.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, Azide-free, HRP) LS-C225346
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

EPHA2 / EPH Receptor A2 Antibody (aa30-60, PE) LS-C225349
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Hamster, Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl  $740.00

IHC-plus™ EPHA2 / EPH Receptor A2 Antibody (clone 1B3C7) LS-B3903
Mouse Monoclonal [clone 1B3C7] (IgM) to Human EPHA2 / EPH Receptor A2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-EPHA2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-EPHA2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

EPHA2 / EPH Receptor A2 Antibody (phospho-Ser897) LS-C329512
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Human
DB, ELISA, WB
Unconjugated
200µl  $590.00

EPHA2 / EPH Receptor A2 Antibody (phospho-Tyr772) LS-C291497
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Human
ELISA, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from brain tissue, using phospho-EphA2 (Phospho-Tyr772) antibody.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using EphA2 (Phospho-Tyr772) Antibody

EPHA2 / EPH Receptor A2 Antibody (APC) LS-C36250
Rat Monoclonal (IgG2b) to Mouse EPHA2 / EPH Receptor A2
Mouse
Flo
APC Conjugated
100tst  $710.00

EPHA2 / EPH Receptor A2 Antibody (clone PAT66G9AT) LS-C760753
Mouse Monoclonal [clone PAT66G9AT] (IgG2b,k) to Human EPHA2 / EPH Receptor A2
Human
ELISA, Flo, ICC, WB
Unconjugated
5µg  $195.00; 20µg  $255.00; 100µg  $475.00

EPHA2 / EPH Receptor A2 Antibody (clone AT66G9) LS-C755452
Mouse Monoclonal [clone AT66G9] (IgG2b,k) to Human EPHA2 / EPH Receptor A2
Human
ELISA, Flo, ICC, WB
Unconjugated
50µl 1mg/ml  $275.00; 100µl 1mg/ml  $345.00
ICC/IF analysis of EPHA2 in HeLa cell line, stained monoclonal anti-human EPHA2 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).ICC/IF analysis of EPHA2 in A431 cell line, stained monoclonal anti-human EPHA2 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
The cell lysate (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human EPHA2 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1 : PC3 cell lysate Recombinant proteins (20ng) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human EPHA2 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1 : Recombinant human EPHA2 extracellular domain Lane 2 : Recombinant human EPHA2 cytoplasmic domain

EPHA2 / EPH Receptor A2 Antibody LS-C670113
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of A549 cells at a dilution of 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 °C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L) .

EPHA2 / EPH Receptor A2 Antibody (Human Ephrin Type A receptor 2, clone 1C1) LS-C777408
Rabbit Recombinant Monoclonal [clone 1C1] (IgG,k) to Human EPHA2 / EPH Receptor A2
Human
Agon, ELISA, Flo, IF, WB
Unconjugated
0.2mg 1mg/ml  $405.00
Immunofluorescence imaging on fixed LL/2 cells.
Immunofluorescence imaging on fixed LL/2 cells.

EPHA2 / EPH Receptor A2 Antibody (Human Ephrin Type A receptor 2, clone 1C1) LS-C777409
Human Recombinant Monoclonal [clone 1C1] (IgG1,k) to Human EPHA2 / EPH Receptor A2
Human
Agon, ELISA, Flo, IF, WB
Unconjugated
0.2mg 1mg/ml  $405.00
Immunofluorescence imaging on fixed LL/2 cells.
Immunofluorescence imaging on fixed LL/2 cells.

EPHA2 / EPH Receptor A2 Antibody LS-C6535
Mouse Monoclonal (IgG1) to Human EPHA2 / EPH Receptor A2
Mouse, Dog, Bovine, Rat, Human
Func, ICC, IP, WB
Unconjugated
200µg  $770.00

EPHA2 / EPH Receptor A2 Antibody LS-C496644
Rabbit Polyclonal (IgG) to Human EPHA2 / EPH Receptor A2
Mouse, Human
Flo, IHC, WB
Unconjugated
100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of MCF-7 cells, using EPHA2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Showing 1-25 of 117 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).