EPHA2 / EPH Receptor A2

EPH receptor A2

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

EPHA2 / EPH Receptor A2 (14)

Publications

No (14)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, C-terminus (2)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (2)

GST (1)

GST, N-terminus (1)

His,C-terminus (1)

His/GST,N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (12)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (4)

Human Cells (2)

Insect Cells (1)

Mammalian Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (6)

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant 6His, C-terminus) (Ala24-Asn534) - LS-G40330

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$725; 1 mg/$1,113

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G137009

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

38.3 kDa

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Mouse EPHA2 / EPH Receptor A2 Protein (Recombinant His,C-terminus) (Met1-Asn535) - LS-G138462

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58 kDa

Price:

100 µg/$793

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant DDK,C-terminus) - LS-G142367

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

56.4 kDa

Price:

20 µg/$677

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142209

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

59 kDa

Price:

20 µg/$1,107

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EPHA2 / EPH Receptor A2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116643

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

100 µg/$494

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant GST) (Full Length) - LS-G28320

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

134.7 kDa

Price:

2 µg/$439

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Human EPHA2 / EPH Receptor A2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75743

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

20 µg/$150

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant GST, N-terminus) (aa204-326) - LS-G58429

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65528

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108.1 kDa

Price:

20 µg/$1,107

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant Fc, C-terminus) (Ala24-Asn534) - LS-G40276

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant 6His, C-terminus) (Ala24-Asn534) - LS-G138710

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.0 kDa

Price:

10 µg/$248; 50 µg/$317

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Human EPHA2 / EPH Receptor A2 Protein (Recombinant His/GST,N-terminus) (Leu585-Ile976) - LS-G139992

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.1 kDa

Price:

50 µg/$707

Select

Human EPHA2 / EPH Receptor A2 Protein (Recombinant Fc, C-terminus) (Ala24-Asn534) - LS-G139075

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.0 kDa

Price:

10 µg/$281; 50 µg/$389

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