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ENTPD5 / CD39L4

ectonucleoside triphosphate diphosphohydrolase 5

Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

Gene Name: ectonucleoside triphosphate diphosphohydrolase 5
Synonyms: ENTPD5, CD39L4, CD39 antigen-like 4, CD39-like 4, GDPase ENTPD5, PCPH, NTPDase 5, Nucleoside diphosphatase, UDPase ENTPD5, ER-UDPase, Guanosine-diphosphatase ENTPD5, NTPDase-5, Pcph proto-oncogene protein, Proto-oncogene CPH, Uridine-diphosphatase ENTPD5
Target Sequences: NM_001249 NP_001240.1 O75356

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ENTPD5 / CD39L4 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His,C-terminus (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (1)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (2)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (2)
ENTPD5 / CD39L4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ENTPD5 / CD39L4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.3 kDa
20 µg/$215
ENTPD5 / CD39L4 Protein - 12.5% SDS-PAGE of human ENTPD5 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.18 kDa
10 µg/$479; 25 µg/$670
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Insect Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47 kDa
50 µg/$854
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Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
46.6 kDa
50 µg/$854
ENTPD5 / CD39L4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.3 kDa
100 µg/$710
ENTPD5 / CD39L4 Protein - Purified recombinant protein ENTPD5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.3 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).