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ENPP2 / Autotaxin

ectonucleotide pyrophosphatase/phosphodiesterase 2

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Family/Subfamily: Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other
Synonyms: ENPP2, AUTOTAXIN, Autotaxin-t, ATX-X, E-NPP 2, LysoPLD, NPP2, PDNP2, PD-IALPHA, Plasma lysophospholipase D, Phosphodiesterase I alpha
Target Sequences: NM_006209 NP_006200.3 Q13822

Publications (3)

1
Autotaxin/lysophosphatidic acid signaling mediates obesity-related cardiomyopathy in mice and human subjects. Weng J, Jiang S, Ding L, Xu Y, Zhu X, Jin P. Journal of cellular and molecular medicine. 2019 February;23:1050-1058. [Full Text Article] [PubMed:30450805] [PMC:PMC6349211]
2
Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice. Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu, Bo Yu. Journal of molecular endocrinology. 2019 August;63:113-121. [Full Text Article] [PubMed:31247591]
3
Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model. Gang Ren, Jiang-Hong Guo, Chen-Lin Feng, Yu-Wei Ding, Biao Dong, Yan-Xing Han, Yu-Huan Li, Lu-Lu Wang, Jian-Dong Jiang. Molecular therapy oncolytics. 2022 September;26:372-386. [Full Text Article] [PubMed:36090480] [PMC:PMC9420352]

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ELISA Kits (11)
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ENPP2 / Autotaxin (11)
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Mouse (3)
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ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
ENPP2 / Autotaxin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$893
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$579
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
Human
625 - 40000 pg/ml
Cell Culture Supernatants, Heparin Plasma, Human Milk, Serum, Urine
1 Plate/$1,150
ENPP2 / Autotaxin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$834
ENPP2 / Autotaxin ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
ENPP2 / Autotaxin ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
ENPP2 / Autotaxin ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$672
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).