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ENPP2 / Autotaxin
ectonucleotide pyrophosphatase/phosphodiesterase 2
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
| Gene Name: | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| Family/Subfamily: | Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other |
| Synonyms: | ENPP2, AUTOTAXIN, Autotaxin-t, ATX-X, E-NPP 2, LysoPLD, NPP2, PDNP2, PD-IALPHA, Plasma lysophospholipase D, Phosphodiesterase I alpha |
| Target Sequences: | NM_006209 NP_006200.3 Q13822 |
Publications (3)
1
Autotaxin/lysophosphatidic acid signaling mediates obesity-related cardiomyopathy in mice and human subjects. Weng J, Jiang S, Ding L, Xu Y, Zhu X, Jin P. Journal of cellular and molecular medicine. 2019 February;23:1050-1058. [Full Text Article]
[PubMed:30450805]
[PMC:PMC6349211]
2
Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice. Yousheng Xu, Yongshun Wang, Jingjin Liu, Wei Cao, Lili Li, Hongwei Du, Enbo Zhan, Ruoxi Zhang, Huimin Liu, Maoen Xu, Tao Chen, Yilin Qu, Bo Yu. Journal of molecular endocrinology. 2019 August;63:113-121. [Full Text Article]
[PubMed:31247591]
3
Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model. Gang Ren, Jiang-Hong Guo, Chen-Lin Feng, Yu-Wei Ding, Biao Dong, Yan-Xing Han, Yu-Huan Li, Lu-Lu Wang, Jian-Dong Jiang. Molecular therapy oncolytics. 2022 September;26:372-386. [Full Text Article]
[PubMed:36090480]
[PMC:PMC9420352]
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(56)
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(56)
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ENPP2 / Autotaxin
(56)
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(46)
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(19)
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(15)
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(3)
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(1)
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(3)
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(3)
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(3)
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(4)
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(12)
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(11)
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(45)
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(7)
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(15)
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(46)
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(3)
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(21)
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(8)
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(9)
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(47)
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13
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(6)
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(3)
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(6)
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(5)
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(4)
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(3)
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(25)
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(9)
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(8)
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(7)
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(4)
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(4)
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(1)
aa369-391
(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(56)
ENPP2 / Autotaxin Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
ENPP2 / Autotaxin Goat anti-Human Polyclonal (aa698-712) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa215-264) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa401-430) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa377-406) Antibody
Human
Flo, WB
Unconjugated
200 µl/$393
ENPP2 / Autotaxin Rabbit anti-Rat Polyclonal (aa573-588) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$737
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (401-450 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ENPP2 / Autotaxin Mouse anti-Human Monoclonal (aa637-905) (A9) Antibody
Human
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296
ENPP2 / Autotaxin Mouse anti-Human Monoclonal (APC) (A9) Antibody
Human
WB
APC Conjugated
100 µl/$418; 200 µl/$507; 500 µl/$887; 1 ml/$1,051; 2 ml/$1,383; 5 ml/$2,591
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa754-783) (Biotin) Antibody
Mouse, Human
ELISA
Biotin Conjugated
100 µl/$1,109
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa564-863) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
ENPP2 / Autotaxin Rabbit anti-Cynomolgus Polyclonal Antibody
Cynomolgus
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa377-406) Antibody
Human
Flo, WB
Unconjugated
200 µl/$734
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa377-406) (Biotin) Antibody
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa377-406) (PE) Antibody
Human
Flo, WB
PE Conjugated
200 µl/$952
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal (aa377-406) (APC) Antibody
Human
Flo, WB
APC Conjugated
200 µl/$952
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ENPP2 / Autotaxin Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
ENPP2 / Autotaxin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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