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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Endothelin 3 / EDN3

endothelin 3

Endothelin 3 / EDN3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: endothelin 3
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: EDN3, Endothelin-3, ET3, Endothelin 3, Preproendothelin-3, WS4B, ET-3, HSCR4, PPET3
Target Sequences: NM_000114 NP_000105.1 P14138

Filtered by: None
Target
Endothelin 3 / EDN3 (45)
Reactivity
Human (37)
Mouse (2)
Rat (10)
Gibbon (3)
Monkey (4)
Pig (6)
Rabbit (1)
Application
IHC (11)
IHC-P (1)
WB (37)
ELISA (13)
IF (1)
IP (1)
Host
rabbit (42)
mouse (3)
Isotype
IgG (24)
IgG1 (2)
IgG1,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (42)
Clone
2A6-2A4 (1)
OTI3E10 (2)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (20)
Epitope
C-Terminus (8)
aa168-197 (8)
aa20-167 (8)
aa17-238 (2)
aa1-217 (1)
Publications
No (45)
Showing 1-25 of 45 results

IHC-plus™ Endothelin 3 / EDN3 Antibody (clone 2A6-2A4) LS-B12661
Mouse Monoclonal [clone 2A6-2A4] (IgG1,k) to Human Endothelin 3 / EDN3
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg 0.5mg/ml  $495.00
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
EDN3 monoclonal antibody (M01), clone 2A6-2A4 Western Blot analysis of EDN3 expression in LNCaP.

Endothelin 3 / EDN3 Antibody LS-C143832
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Rat, Pig, Human
IF, IHC
Unconjugated
50µl  $495.00

Endothelin 3 / EDN3 Antibody LS-C400737
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, IHC
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using EDN3 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of paraffin-embedded Human thyroid cancer using EDN3 Polyclonal Antibody at dilution of 1:30.

Endothelin 3 / EDN3 Antibody LS-C806022
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

Endothelin 3 / EDN3 Antibody (aa17-238, clone OTI3E10) LS-C799019
Mouse Monoclonal [clone OTI3E10] (IgG1) to Human Endothelin 3 / EDN3
Human
IHC
Unconjugated
100µl 1mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)

Endothelin 3 / EDN3 Antibody (aa17-238, clone OTI3E10, Carrier-free) LS-C791711
Mouse Monoclonal [clone OTI3E10] (IgG1) to Human Endothelin 3 / EDN3
Human
IHC
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)

Endothelin 3 / EDN3 Antibody LS-C193964
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
IHC, WB
Unconjugated
50µg 1ml  $860.00

Endothelin 3 / EDN3 Antibody LS-C341453
Rabbit Polyclonal to Human Endothelin 3 / EDN3
Human
IHC, WB
Unconjugated
100µl 1mg/ml  $385.00

Endothelin 3 / EDN3 Antibody LS-C403990
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, IHC
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using EDN3 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human thyroid cancer using EDN3 Polyclonal Antibody at dilution of 1:40.

Endothelin 3 / EDN3 Antibody LS-C401645
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, IHC
Unconjugated
20µl 0.6mg/ml  $205.00; 60µl 0.6mg/ml  $235.00; 120µl 0.6mg/ml  $295.00; 200µl 0.6mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using EDN3 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of paraffin-embedded Human liver cancer using EDN3 Polyclonal Antibody at dilution of 1:50.

Endothelin 3 / EDN3 Antibody (aa168-197) LS-C321024
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
Unconjugated
200µl  $590.00

Endothelin 3 / EDN3 Antibody (aa168-197, Biotin) LS-C208863
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

Endothelin 3 / EDN3 Antibody (aa168-197, FITC) LS-C208864
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

Endothelin 3 / EDN3 Antibody (aa168-197, AP) LS-C208861
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
AP Conjugated
200µl  $740.00

Endothelin 3 / EDN3 Antibody (aa168-197, APC) LS-C208862
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
APC Conjugated
200µl  $740.00

Endothelin 3 / EDN3 Antibody (aa168-197, PE) LS-C208866
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
PE Conjugated
200µl  $740.00

Endothelin 3 / EDN3 Antibody (aa168-197, Azide-free, HRP) LS-C208865
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

Endothelin 3 / EDN3 Antibody LS-C748990
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Mouse, Human
IHC
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00

Endothelin 3 / EDN3 Antibody LS-C143833
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Rabbit, Pig, Human
ELISA
Unconjugated
400µg  $725.00

Endothelin 3 / EDN3 Antibody LS-C311104
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
WB
Unconjugated
100µg  $605.00

Endothelin 3 / EDN3 Antibody (C-Terminus) LS-C135938
Rabbit Polyclonal to Human Endothelin 3 / EDN3
Pig, Human
WB
Unconjugated
100µl 0.5mg/ml  $365.00
EDN3 / Endothelin 3 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Endothelin 3 / EDN3 Antibody (C-Terminus) LS-C151427
Rabbit Polyclonal to Human Endothelin 3 / EDN3
Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
Endothelin 3 / EDN3 antibody Western Blot of PANC1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Endothelin 3 / EDN3 Antibody (aa1-217) LS-C186324
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
WB
Unconjugated
100µl 0.52mg/ml  $355.00
Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. Endothelin 3 / EDN3 antibody diluted at 1:1000.

Endothelin 3 / EDN3 Antibody (aa168-197) LS-C167626
Rabbit Polyclonal to Human Endothelin 3 / EDN3
Human
WB
Unconjugated
400µl  $325.00
EDN3 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The EDN3 antibody detected the EDN3 protein (arrow).

Endothelin 3 / EDN3 Antibody LS-C331219
Rabbit Polyclonal (IgG) to Human Endothelin 3 / EDN3
Human
WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cell lines, using EDN3 antibody.
Western blot analysis of extracts of A-549 cells, using EDN3 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 20s.
Showing 1-25 of 45 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).