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Endothelin 3 / EDN3

endothelin 3

Endothelin 3 / EDN3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: endothelin 3
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: EDN3, Endothelin-3, ET3, Endothelin 3, Preproendothelin-3, WS4B, ET-3, HSCR4, PPET3
Target Sequences: NM_000114 NP_000105.1 P14138

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Products
Antibodies (42)
Primary (42)
Endothelin 3 / EDN3 (42)
Human (34)
Mouse (2)
Rat (10)
Gibbon (3)
Monkey (4)
Pig (6)
Rabbit (1)
IHC (8)
IHC-P (1)
WB (35)
ELISA (12)
IF (1)
IP (1)
rabbit (39)
mouse (3)
Product Group
IHCPlus (1)
IgG (22)
IgG1 (2)
IgG1,k (1)
monoclonal mc (3)
polyclonal pc (39)
2A6-2A4 (1)
OTI3E10 (2)
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (17)
C-Terminus (8)
aa168-197 (8)
aa20-167 (8)
aa17-238 (2)
aa1-217 (1)
No (42)
Endothelin 3 / EDN3 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (2A6-2A4) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$495
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Rat, Pig, Human
IF, IHC
Unconjugated
50 µl/$537
Endothelin 3 / EDN3 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using EDN3 Polyclonal Antibody at dilution of 1:30.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
Endothelin 3 / EDN3 Antibody - 1:100 staining human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
Endothelin 3 / EDN3 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (aa17-238) (OTI3E10) Antibody
Human
IHC
Unconjugated
100 µl/$390
Endothelin 3 / EDN3 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (aa17-238) (Carrier-free) (OTI3E10) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$448
Endothelin 3 / EDN3 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using EDN3 Polyclonal Antibody at dilution of 1:50.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$614
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$767
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$767
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$767
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$767
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$767
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$767
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Rabbit, Pig, Human
ELISA
Unconjugated
400 µg/$762
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$622
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$774
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$774
Select
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (AP) Antibody
Human
WB
AP Conjugated
100 µl/$774
Endothelin 3 / EDN3 Antibody - EDN3 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The EDN3 antibody detected the EDN3 protein (arrow).
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) Antibody
Human
WB
Unconjugated
400 µl/$376
Endothelin 3 / EDN3 Antibody - Endothelin 3 / EDN3 antibody Western Blot of PANC1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
WB
Unconjugated
100 µl/$396
Endothelin 3 / EDN3 Antibody - EDN3 / Endothelin 3 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Pig, Human
WB
Unconjugated
100 µl/$396
Endothelin 3 / EDN3 Antibody - Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. Endothelin 3 / EDN3 antibody diluted at 1:1000.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa1-217) Antibody
Human
WB
Unconjugated
100 µl/$398
Endothelin 3 / EDN3 Antibody - Western blot analysis of extracts of various cell lines, using EDN3 antibody.
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Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).