Endostatin

collagen, type XVIII, alpha 1

Endostatin is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

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Proteins (13)

Type

Recombinant (13)

Target

Endostatin (13)

Publications

No (13)

Tag

6His, C-terminus (2)

His (2)

His, N-Terminal (2)

His-GST (1)

His-T7 (1)

Species

Human (7)

Mouse (4)

Rat (2)

Source

293F Cells (1)

E. coli (6)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Yeast (3)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (5)

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Human Endostatin Protein (Recombinant His-T7) (aa1572-1754) - LS-G14809

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.9 kDa

Price:

10 µg/$265; 50 µg/$347; 100 µg/$545; 200 µg/$682; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866

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Human Endostatin Protein (Recombinant His, N-Terminal) (His1154-Ser1335) - LS-G132874

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

21kDa

Price:

10 µg/$299; 50 µg/$552; 200 µg/$1,080; 100 µg/$882; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Mouse Endostatin Protein (Recombinant 6His, C-terminus) (His1591-Lys1774) - LS-G139247

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.2 kDa

Price:

10 µg/$277; 50 µg/$389

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Human Endostatin Protein (Recombinant His) (aa1578-1754) - LS-G22869

Source:

Yeast

Tag:

His

Molecular Weight:

21.3 kD

Price:

1 mg/$1,607; 100 µg/$469; 20 µg/$349

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Human Endostatin Protein (Recombinant) - LS-G27307

Source:

Yeast

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein.

Price:

100 µg/$304

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Human Endostatin Protein (Recombinant) - LS-G133

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

20.2 kDa

Price:

20 µg/$268; 100 µg/$349

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Human Endostatin Protein (Recombinant) - LS-G137713

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 192 amino acid recombinant protein has a predicted molecular mass of approximately 21.3 kD. The DTT-reduced and non-reduced protein migrate at approximately 23 and 20 kD respectively by SDS-PAGE. The predicted N-terminal amino acid is Met.

Price:

25 µg/$283; 100 µg/$355

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Mouse Endostatin Protein (Recombinant) - LS-G137712

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The 192 amino acid recombinant protein has a predicted molecular mass of approximately 21.3 kD. The DTT-reduced and non-reduced protein migrate at approximately 23 and 20 kD respectively by SDS-PAGE. The predicted N-terminal amino acid is His.

Price:

25 µg/$283; 100 µg/$352; 500 µg/$582

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Human Endostatin Protein (Recombinant) - LS-G27305

Source:

Yeast

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.4 kDa (SDS-PAGE)

Price:

50 µg/$304; 10 µg/$262; 1 mg/$990

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Mouse Endostatin Protein (Recombinant 6His, C-terminus) (His1591-Lys1774) - LS-G51844

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21.2kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627

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Rat Endostatin Protein (Recombinant His-GST) (aa1072-1271) - LS-G14807

Source:

E. coli

Tag:

His-GST

Molecular Weight:

54.5 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Mouse Endostatin Protein (Recombinant His) (aa1591-1774) - LS-G14811

Source:

E. coli

Tag:

His

Molecular Weight:

21.9 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Rat Endostatin Protein (Recombinant His, N-Terminal) (Ser1296-Gly1488) - LS-G133066

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

48.7kDa

Price:

10 µg/$284; 50 µg/$462; 200 µg/$922; 100 µg/$737; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,681

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