Endonuclease G / ENDOG

endonuclease G

The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndooG also cleaves DNA in vitro.

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Proteins (6)

Type

Native (1)

Over-Expression Lysate (2)

Recombinant (3)

Target

Endonuclease G / ENDOG (6)

Publications

No (6)

Tag

GST (1)

His-GST (1)

His-GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Rat (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Rat (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Rat Endonuclease G / ENDOG Protein (Native His-GST, N-terminus) - LS-G132753

Source:

Rat

Tag:

His-GST, N-terminus

Molecular Weight:

62kDa

Price:

10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988

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Endonuclease G / ENDOG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116645

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.65 kDa

Price:

100 µg/$494

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Human Endonuclease G / ENDOG Protein (Recombinant His-T7) (aa16-290) - LS-G24867

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Rat Endonuclease G / ENDOG Protein (Recombinant His-GST) (aa1-294) - LS-G24868

Source:

E. coli

Tag:

His-GST

Molecular Weight:

62.3 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human Endonuclease G / ENDOG Protein (Recombinant GST) (Full Length) - LS-G28346

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.02 kDa

Price:

2 µg/$439

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Human Endonuclease G / ENDOG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75716

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.65 kDa

Price:

20 µg/$150

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