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EMG1 / NEP1
EMG1 N1-specific pseudouridine methyltransferase
S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
| Gene Name: | EMG1 N1-specific pseudouridine methyltransferase |
| Synonyms: | EMG1, C2F, BWCNS, Grcc2f, Essential for mitotic growth 1, NEP1, Protein C2f, Nucleolar protein EMG1 homolog |
| Target Sequences: | NM_006331 NP_006322.4 Q92979 |
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