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EMA / MUC1

mucin 1, cell surface associated

EMA / MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Gene Name: mucin 1, cell surface associated
Family/Subfamily: Mucin , not assigned-Mucin
Synonyms: MUC1, CA15-3, CD227, Carcinoma-associated mucin, CD227 antigen, DF3 antigen, Episialin, Epithelial membrane antigen, H23 antigen, H23AG, Krebs von den Lungen-6, MAM6, MUC1/ZD, MUC-1/SEC, Mucin-1, Pem, KL-6, MUC-1/X, Tumor-associated mucin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, PUM, EMA, MUC-1, Mucin 1, transmembrane
Target Sequences: NM_002456 NP_002447.4 P15941

Publications (7)

1
Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden. Kwon WS, Kim TS, Nahm CH, Moon Y, Kim JJ. Oncology letters. 2018 November;16:5583-5590. [Full Text Article] [PubMed:30344712] [PMC:PMC6176264]
2
Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. Elena Zagato , Chiara Pozzi , Alice Bertocchi, Tiziana Schioppa, Fabiana Saccheri, Silvia Guglietta, Bruno Fosso, Laura Melocchi, Giulia Nizzoli, Jacopo Troisi, Marinella Marzano, Bianca Oresta, Ilaria Spadoni, Koji Atarashi, Sara Carloni, Stefania Arioli, Giulia Fornasa, Francesco Asnicar, Nicola Segata, Simone Guglielmetti, Kenya Honda, Graziano Pesole, William Vermi, Giuseppe Penna, Maria Rescigno. Nature microbiology. 2020 March;5:511-524. [Full Text Article] [PubMed:31988379] [PMC:PMC7048616] Related Antibodies: LS-C343984.
3
Serum concentration of sex hormone-binding globulin in healthy volunteers and patients with breast cancer stratified by sex and age. Se Jung Park, Tae Soo Kim, Kyu Hyun Park, Woo Sun Kwon, Jin Ju Kim. Oncology letters. 2020 July;20:364-372. [Full Text Article] [PubMed:32565962] [PMC:PMC7285803]
4
Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis. Irina G Luzina, Erik P Lillehoj, Virginia Lockatell, Sang W Hyun, Katerina N Lugkey, Akihiro Imamura, Hideharu Ishida, Christopher W Cairo, Sergei P Atamas, Simeon E Goldblum. The Journal of pharmacology and experimental therapeutics. 2020 November; [Full Text Article] [PubMed:33139318] [PMC:PMC7788353] Related Antibodies: LS-C343984.
5
Sublethal Radiation Affects Antigen Processing and Presentation Genes to Enhance Immunogenicity of Cancer Cells. Achamaporn Punnanitinont, Eric D Kannisto, Junko Matsuzaki, Kunle Odunsi, Sai Yendamuri, Anurag K Singh, Santosh K Patnaik. International journal of molecular sciences. 2020 Apr;21:2573. [Full Text Article] [PubMed:32272797] [PMC:PMC7178186] Related Antibodies: LS-B2244.
6
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma. Carolina Martinelli, Fabio Gabriele, Federico Manai, Roberto Ciccone, Francesca Novara, Elisabetta Sauta, Riccardo Bellazzi, Monica Patane, Isabella Moroni, Rosina Paterra, Sergio Comincini. Cancer genomics & proteomics. 2020 Mar-Apr;17:117-130. [Full Text Article] [PubMed:32108034] [PMC:PMC7078841] Related Antibodies: LS-C77445.
7
Immunohistochemical characterization of mesothelioma in 6 large felids. Sarah E Coe, Michael M Garner, Matti Kiupel. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2021 July;33:767-771. [Full Text Article] [PubMed:33980074] [PMC:PMC8229833] Related Antibodies: LS-C30532.
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☰ Filters
Products
Proteins (27)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (8)
Recombinant (18)
EMA / MUC1 (27)
SDS-PAGE (3)
No (27)
6His, N-terminus (1)
Fc (1)
Fc, C-terminus (2)
Fc-AVI, C-terminus (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
His,C-terminus (1)
His-GST (3)
His-GST, N-terminus (1)
His-GST-S (1)
Human IgG Fc, C-terminus (1)
Mouse IgG1 Fc, C-terminus (1)
Myc-DDK (Flag) (9)
Human (18)
Mouse (3)
Rat (2)
293T Cells (4)
E. coli (8)
HEK 293 Cells (10)
Human (1)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (8)
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
17.2 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His-GST
49.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His-GST
59.5 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His
14.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His-GST, N-terminus
49.0 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
EMA / MUC1 Protein - Recombinant Mucin 1 By SDS-PAGE
Select
E. coli
His-GST
45.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
28.4 kDa
100 µg/$494
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.57 kDa
100 µg/$494
Select
HEK 293 Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.4 kDa
100 µg/$982
EMA / MUC1 Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human MUC1 consists of 142 amino and has a predicted molecular mass of 15.4 kDa.
100 µg/$519
Select
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human MUC1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 376 amino acids after removal the signal peptide and has a predicted molecular mass of 42 kDa. As a result of glycosylation, rh MUC1/Fc monomer migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
100 µg/$441
Select
HEK 293 Cells
Mouse IgG1 Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human MUC1/mFc is a disulfide-linked homodimer. The reduced monomer consists of 369 amino acids after removal the signal peptide and has a predicted molecular mass of 41 kDa. As a result of glycosylation, rhMUC1/mFc monomer migrates as an approximately 50.2 and 34.8 kDa band in SDS-PAGE under reducing conditions.
100 µg/$441
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3 kDa
10 µg/$277; 50 µg/$389
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16.25 kDa
100 µg/$494
EMA / MUC1 Protein
Select
E. coli
His, N-Terminal
25.1 kDa
50 µg/$419
EMA / MUC1 Protein - Recombinant Human Mucin-1/MUC-1 (C-Fc-Avi) Biotinylated
Select
Human
Fc-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44 kDa
20 µg/$416; 100 µg/$910
EMA / MUC1 Protein - Recombinant  Mucin 1 By SDS-PAGE
Select
E. coli
His-GST-S
63.0 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
Select
HEK 293 Cells
6His, N-terminus
27 kDa
200 µl/$283
EMA / MUC1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EMA / MUC1 Protein - Purified recombinant protein MUC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
25.1 kDa
20 µg/$1,107
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.57 kDa
20 µg/$150
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16.25 kDa
20 µg/$150
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
28.4 kDa
20 µg/$150
EMA / MUC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
29.59 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).