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EMA / MUC1

mucin 1, cell surface associated

EMA / MUC1 is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.

Gene Name: mucin 1, cell surface associated
Family/Subfamily: Mucin , not assigned-Mucin
Synonyms: MUC1, CA15-3, CD227, Carcinoma-associated mucin, CD227 antigen, DF3 antigen, Episialin, Epithelial membrane antigen, H23 antigen, H23AG, Krebs von den Lungen-6, MAM6, MUC1/ZD, MUC-1/SEC, Mucin-1, Pem, KL-6, MUC-1/X, Tumor-associated mucin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, PUM, EMA, MUC-1, Mucin 1, transmembrane
Target Sequences: NM_002456 NP_002447.4 P15941

Publications (7)

1
Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden. Kwon WS, Kim TS, Nahm CH, Moon Y, Kim JJ. Oncology letters. 2018 November;16:5583-5590. [Full Text Article] [PubMed:30344712] [PMC:PMC6176264]
2
Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. Elena Zagato , Chiara Pozzi , Alice Bertocchi, Tiziana Schioppa, Fabiana Saccheri, Silvia Guglietta, Bruno Fosso, Laura Melocchi, Giulia Nizzoli, Jacopo Troisi, Marinella Marzano, Bianca Oresta, Ilaria Spadoni, Koji Atarashi, Sara Carloni, Stefania Arioli, Giulia Fornasa, Francesco Asnicar, Nicola Segata, Simone Guglielmetti, Kenya Honda, Graziano Pesole, William Vermi, Giuseppe Penna, Maria Rescigno. Nature microbiology. 2020 March;5:511-524. [Full Text Article] [PubMed:31988379] [PMC:PMC7048616] Related Antibodies: LS-C343984.
3
Serum concentration of sex hormone-binding globulin in healthy volunteers and patients with breast cancer stratified by sex and age. Se Jung Park, Tae Soo Kim, Kyu Hyun Park, Woo Sun Kwon, Jin Ju Kim. Oncology letters. 2020 July;20:364-372. [Full Text Article] [PubMed:32565962] [PMC:PMC7285803]
4
Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis. Irina G Luzina, Erik P Lillehoj, Virginia Lockatell, Sang W Hyun, Katerina N Lugkey, Akihiro Imamura, Hideharu Ishida, Christopher W Cairo, Sergei P Atamas, Simeon E Goldblum. The Journal of pharmacology and experimental therapeutics. 2020 November; [Full Text Article] [PubMed:33139318] [PMC:PMC7788353] Related Antibodies: LS-C343984.
5
Sublethal Radiation Affects Antigen Processing and Presentation Genes to Enhance Immunogenicity of Cancer Cells. Achamaporn Punnanitinont, Eric D Kannisto, Junko Matsuzaki, Kunle Odunsi, Sai Yendamuri, Anurag K Singh, Santosh K Patnaik. International journal of molecular sciences. 2020 Apr;21:2573. [Full Text Article] [PubMed:32272797] [PMC:PMC7178186] Related Antibodies: LS-B2244.
6
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma. Carolina Martinelli, Fabio Gabriele, Federico Manai, Roberto Ciccone, Francesca Novara, Elisabetta Sauta, Riccardo Bellazzi, Monica Patane, Isabella Moroni, Rosina Paterra, Sergio Comincini. Cancer genomics & proteomics. 2020 Mar-Apr;17:117-130. [Full Text Article] [PubMed:32108034] [PMC:PMC7078841] Related Antibodies: LS-C77445.
7
Immunohistochemical characterization of mesothelioma in 6 large felids. Sarah E Coe, Michael M Garner, Matti Kiupel. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2021 July;33:767-771. [Full Text Article] [PubMed:33980074] [PMC:PMC8229833] Related Antibodies: LS-C30532.
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Products
ELISA Kits (23)
Competitive EIA (4)
Custom (1)
Development Kit (3)
Sandwich (14)
Sandwich CLIA (1)
EMA / MUC1 (23)
Human (8)
Mouse (6)
Rat (3)
Chicken (1)
Guinea pig (1)
Monkey (1)
Rabbit (2)
Product Group
DevKit DuoPlus (3)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (16)
Antibody Pair and Standard (3)
No (22)
Yes (1)
Cell Culture Supernatants (7)
Cell Lysates (6)
Plasma (15)
Saliva (1)
Serum (15)
Tissue Homogenates (9)
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
EMA / MUC1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
EMA / MUC1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$685
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
EMA / MUC1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
4.096 - 1000 mU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
EMA / MUC1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
EMA / MUC1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
EMA / MUC1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
EMA / MUC1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rabbit
50 - 800 IU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
EMA / MUC1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,089; 1000 Wells/$1,589
EMA / MUC1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,207; 1000 Wells/$1,787
EMA / MUC1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Saliva, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
EMA / MUC1 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
EMA / MUC1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
EMA / MUC1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$782
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).