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Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
Gene Name: | ELOVL fatty acid elongase 1 |
Synonyms: | ELOVL1, ELOVL FA elongase 1, ELOVL fatty acid elongase 1, Ssc1, CGI-88 |
Target Sequences: | NM_022821 NP_073732.1 Q9BW60 |
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