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ELF3 / ESE1

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

Gene Name:	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
Synonyms:	ELF3, ERT, ESE-1, ESE1, JEN, ESX, E74-like factor 3, EPR-1
Target Sequences:	NM_004433 NP_004424.3 P78545

Publications (1)

Advancing towards a tissue-engineered tympanic membrane: silk fibroin as a substratum for growing human eardrum keratinocytes. Ghassemifar R, Redmond S, Zainuddin, Chirila TV. Journal of biomaterials applications. 2010 24:591-606. [PubMed:20308345]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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