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EIF5A2

eukaryotic translation initiation factor 5A2

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.

Gene Name: eukaryotic translation initiation factor 5A2
Synonyms: EIF5A2, EIF-5A-2, EIF-5A2, EIF5AII
Target Sequences: NM_020390 NP_065123.1 Q9GZV4

Publications (2)

1
Identification and characterization of eukaryotic initiation factor 5A-2. Clement PM, Henderson CA, Jenkins ZA, Smit-McBride Z, Wolff EC, Hershey JW, Park MH, Johansson HE. European journal of biochemistry / FEBS. 2003 270:4254-63. [PubMed:14622290]
2
Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells. Clement PM, Johansson HE, Wolff EC, Park MH. The FEBS journal. 2006 273:1102-14. [PubMed:16519677]

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
EIF5A2 (8)
No (8)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
EIF5A2 Protein - 12.5% SDS-PAGE of human EIF5A2 stained with Coomassie Blue
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Wheat Germ Extract
GST
42.46 kDa
10 µg/$479; 25 µg/$670
EIF5A2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EIF5A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
16.6 kDa
20 µg/$150
EIF5A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
16.6 kDa
100 µg/$494
EIF5A2 Protein - Purified recombinant protein EIF5A2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
16.6 kDa
20 µg/$1,107
EIF5A2 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.9 kDa
10 µg/$281; 50 µg/$414
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.9kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).