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20700 44th Avenue W
Lynnwood, WA 98036
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EIF5A
eukaryotic translation initiation factor 5A
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
| Gene Name: | eukaryotic translation initiation factor 5A |
| Synonyms: | EIF5A, EIF-4D, EIF-5A, EIF-5A-1, EIF-5A1, EIF5A1, Initiation factor 5a, Rev-binding factor, EIF5AI |
| Target Sequences: | NM_001970 NP_001961.1 P63241 |
Publications (2)
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