EIF4A3

eukaryotic translation initiation factor 4A3

ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. Involved in craniofacial development.

☰ Filters

Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

EIF4A3 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human EIF4A3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65579

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

20 µg/$1,107

Select

Human EIF4A3 Protein (Recombinant GST, N-terminus) (aa312-411) - LS-G61244

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human EIF4A3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75837

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

20 µg/$150

Select

Human EIF4A3 Protein (Recombinant GST) (Full Length) - LS-G31799

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.3 kDa

Price:

10 µg/$479; 25 µg/$670

Select

EIF4A3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101253

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

100 µg/$494

Select

Human EIF4A3 Protein (Recombinant His) - LS-G1554

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Viewing 1-6 of 6 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.