Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
|Gene Name:||eukaryotic translation initiation factor 3, subunit J|
|Synonyms:||EIF3J, EIF3 p35, EIF3-alpha, EIF3S1, EIF-3-alpha, EIF3-p35|
|Target Sequences:||NM_003758 NP_003749.2 O75822|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.