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EIF2S3 / EIF2G
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
| Gene Name: | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
| Synonyms: | EIF2S3, EIF-2-gamma X, EIF2, EIF2gamma, EIF-2gA, EIF-2gX, EIF2G |
| Target Sequences: | NM_001415 NP_001406.1 P41091 |
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