EIF2S1

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

EIF2 is a translation initiation factor that catalyzes the first regulated step of protein synthesis, promoting the binding of the initiator tRNA to 40s ribosomal subunits. eIF2 is composed of 3 non identical subunits, alpha, beta and gamma. Binding occurs as a ternary complex of methionyl-tRNA, eIF2 and GTP. The rate of complex formation is modulated by the phosphorylation state of eIF2alpha. Phosphorylation of eIF2alpha has been shown to occur in response to heat shock and hypoxic stress. Once eIF2alpha is phosphorylated, the initiation of protein synthesis is inhibited. Expression of eIF-2alpha has been shown to increase in melanoma and colon carcinoma.

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ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Target

EIF2S1 (2)

Reactivity

Human (2)

Mouse (2)

Rat (2)

Format

96-Well Microplate (2)

Publications

No (2)

Sample Type

Adherent Cell Cultures (2)

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Mouse/Human/Rat Phospho-EIF2S1 (Ser51) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1494

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat EIF2S1 (Cell-Based ELISA) ELISA Kit - LS-F1959

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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