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EIF2AK3 / PERK

eukaryotic translation initiation factor 2-alpha kinase 3

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Gene Name: eukaryotic translation initiation factor 2-alpha kinase 3
Family/Subfamily: Protein Kinase , Translational Control Kinase
Synonyms: EIF2AK3, HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PERK, PKR-like ER kinase, WRS
Target Sequences: NM_004836 NP_004827.4 Q9NZJ5

Publications (3)

1
Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2a-dependent translational attenuation and insulin biosynthesis in pancreatic ß cells. Akai R, Hosoda A, Yoshino M, Iwawaki T. Genes to cells : devoted to molecular & cellular mechanisms. 2015 November;20:871-86. [Full Text Article] [PubMed:26314560]
2
Linagliptin and Vitamin D3 Synergistically Rescue Testicular Steroidogenesis and Spermatogenesis in Cisplatin-Exposed Rats: The Crosstalk of Endoplasmic Reticulum Stress with NF-?B/iNOS Activation. Rania A Elrashidy, Esraa M Zakaria, Asmaa M Elmaghraby, Rasha E M Abd El Aziz, Ranya M Abdelgalil, Rehab M Megahed, Asmaa A Elshiech, Doaa E A Salama, Samah E Ibrahim. Molecules (Basel, Switzerland). 2022 October;27: [Full Text Article] [PubMed:36364125] [PMC:PMC9657441]
3
Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Vong CT, Tseng HH, Kwan YW, Lee SM, Hoi MP. Frontiers in pharmacology. 2016 7:67. (WB; Human) [Full Text Article] [PubMed:27047382] [PMC:PMC4800184] Related Antibodies: LS-C118320.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
EIF2AK3 / PERK (5)
No (5)
GST, N-terminus (1)
His-S (1)
Myc-DDK (Flag) (3)
Human (3)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
EIF2AK3 / PERK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
125.26 kDa
20 µg/$215
EIF2AK3 / PERK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
EIF2AK3 / PERK Protein - Purified recombinant protein EIF2AK3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
122.1 kDa
20 µg/$1,107
EIF2AK3 / PERK Protein - Recombinant Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 By SDS-PAGE
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E. coli
His-S
23.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
EIF2AK3 / PERK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
125.26 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).