EHMT2 / G9A

euchromatic histone-lysine N-methyltransferase 2

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

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Proteins (5)

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Over-Expression Lysate (4)

Recombinant (1)

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EHMT2 / G9A (5)

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Myc-DDK (Flag) (5)

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Human (3)

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293T Cells (2)

HEK 293 Cells (3)

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Human EHMT2 / G9A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69168

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.8 kDa

Price:

20 µg/$1,107

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Human EHMT2 / G9A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83977

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.8 kDa

Price:

20 µg/$215

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EHMT2 / G9A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115132

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.2 kDa

Price:

100 µg/$710

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EHMT2 / G9A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109505

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.8 kDa

Price:

100 µg/$710

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Human EHMT2 / G9A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83978

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

132.2 kDa

Price:

20 µg/$215

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