EGFR

epidermal growth factor receptor

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.

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Products

ELISA Kits (45)

Type

Cell-Based (1)

Cell-Based Phosphorylation (16)

Competitive EIA (1)

Custom (3)

Sandwich (21)

Sandwich CLIA (2)

Sandwich Phosphorylation (1)

Target

EGFR (45)

Reactivity

Human (30)

Mouse (24)

Rat (18)

Chicken (2)

Equine (1)

Monkey (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (24)

96-Well Strip Plate (19)

Publications

No (45)

Sample Type

Adherent Cell Cultures (17)

Breast Milk (1)

Cell Culture Supernatants (5)

Cell Lysates (4)

Plasma (21)

Serum (21)

Tissue Homogenates (6)

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Human EGFR (Sandwich ELISA) ELISA Kit - LS-F10113

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$725

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Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F5373

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Human EGFR (Sandwich ELISA) ELISA Kit - LS-F70

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.743 - 666.7 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$588

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Human EGFR (Sandwich ELISA) ELISA Kit - LS-F13162

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

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Mouse/Human/Rat Phospho-EGFR (Tyr992) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F942

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$556

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Rat EGFR (Sandwich ELISA) ELISA Kit - LS-F5030

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$818

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Human Phospho-EGFR ELISA Kit - LS-F334

Type:

Sandwich Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$728

Select

Equine EGFR (Custom ELISA) ELISA Kit - LS-F50131

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Equine

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$923

Select

Chicken EGFR (Sandwich ELISA) ELISA Kit - LS-F43595

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$627

Select

Rabbit EGFR (Sandwich ELISA) ELISA Kit - LS-F43596

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Monkey EGFR (Sandwich ELISA) ELISA Kit - LS-F43597

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$627

Select

Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F39719

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$795

Select

Mouse EGFR (Custom ELISA) ELISA Kit - LS-F15162

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$685

Select

Chicken EGFR (Custom ELISA) ELISA Kit - LS-F15163

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F21896

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$626

Select

Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F23548

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F24485

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F34623

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F32100

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human EGFR (CLIA) ELISA Kit - LS-F29035

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

8 - 500 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$649

Select

Human EGFR (CLIA) ELISA Kit - LS-F29112

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse EGFR (Sandwich ELISA) ELISA Kit - LS-F31719

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

Select

Rat EGFR (Sandwich ELISA) ELISA Kit - LS-F27420

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Mouse EGFR (Competitive EIA) ELISA Kit - LS-F28323

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Human EGFR (Sandwich ELISA) ELISA Kit - LS-F26858

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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