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Unfortunately, the antibody (ID:120471) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



EGFR

epidermal growth factor receptor

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.

Gene Name: epidermal growth factor receptor
Family/Subfamily: Protein Kinase , EGF Receptor
Synonyms: EGFR, EGFf receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1
Target Sequences: NM_005228 NP_005219.2 P00533

Publications (5)

1
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L314-27. (WB) [PubMed:17468132]
2
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells. Kumar N, Afeyan R, Kim HD, Lauffenburger DA. Molecular pharmacology. 2008 73:1668-78. (ICC) [PubMed:18349105]
3
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU, Bae SS, Kim CD. Toxicology and applied pharmacology. 2010 245:76-82. (WB) [PubMed:20153347]
4
Nuclear translocation of type I transforming growth factor receptor confers a novel function in RNA processing. Chandra M, Zang S, Li H, Zimmerman LJ, Champer J, Tsuyada A, Chow A, Zhou W, Yu Y, Gao H, Ren X, Lin RJ, Wang SE. Molecular and cellular biology. 2012 32:2183-95. [PubMed:22473997] [PMC:PMC3372271] Related Antibodies: LS-C100292.
5
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Nature. 2013 Jul;499:166-71. [Full Text Article] [PubMed:23846654] Related Antibodies: LS-C6640.
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Filtered By: None
Target
egfr (571)
Reactivity
Human (553)
Mouse (173)
Rat (146)
Bovine (6)
Chicken (12)
Dog (12)
Gibbon (3)
Horse (11)
Monkey (19)
Pig (6)
Rabbit (1)
Rhesus monkey (2)
Zebrafish (7)
Application
IHC (113)
IHC-Fr (10)
IHC-P (91)
WB (410)
Flo (82)
Block (7)
DB (30)
ELISA (200)
EM (1)
Func (3)
ICC (58)
IF (82)
Inhb (4)
IP (154)
Neut (7)
PLA (1)
Purif (1)
Host
rabbit (314)
mouse (224)
goat (3)
human (1)
rat (21)
sheep (8)
Isotype
IgG (226)
IgG1 (88)
IgG1 + IgG2a (6)
IgG1,k (37)
IgG2a (57)
IgG2a,k (7)
IgG2b (13)
IgG2b,k (11)
Clonality
monoclonal mc (247)
polyclonal pc (324)
Clone
111.6 (4)
111.6+199.12+ F4+11E8 (2)
11H7 (1)
199.12 (2)
1A3 (1)
1B10 (1)
1B6 (1)
1C8 (1)
1E5 (1)
225 (3)
2E1 (1)
2E9 (1)
2G8 (1)
31G7 (6)
31G7 + GFR1195 (3)
3D7 (1)
3F2 (1)
3H2 (1)
423103 (1)
4G3 (1)
4H2 (1)
51CT78.40.5 (1)
528 (3)
528 + 199.12 (3)
5E10D3 (1)
5G9B5 (2)
688CT33.1.3 (5)
6E3 (1)
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813182 (1)
8E6 (1)
9F12 (1)
9G6 (1)
9H2 (1)
A20-E (1)
AT2H8 (1)
AT6E3 (1)
B1D8 (2)
EGFR.1 (3)
EGFR1 (2)
EGF-R1 (1)
EGF-R2 (1)
ERB59-1 (2)
ERB7-1 (3)
GFR1195 (3)
GFR450 (2)
H11 (3)
H9B4 (4)
ICR10 (2)
M6 (1)
SB41a (1)
SP111 (1)
SP125 (1)
SP84 (1)
SPM341 (1)
SPM622 (3)
Format
AF488 Conjugated (1)
AP Conjugated (34)
APC Conjugated (31)
Azide-free (29)
Biotin Conjugated (48)
FITC Conjugated (42)
HRP Conjugated (37)
PE Conjugated (35)
Ready-to-Use (6)
RPE Conjugated (1)
Unconjugated (342)
Epitope
C-Terminus (15)
aa900-1210 (15)
pTyr1172 (15)
pTyr1016 (12)
Ser1070 (8)
Tyr978 (8)
aa259-287 (8)
pTyr1125 (8)
pTyr1197 (8)
Extracellular Domain (7)
aa1004-1033 (7)
pSer768 (7)
pThr693 (7)
aa713-984 (6)
pSer1070 (6)
pThr678 (6)
pTyr1110 (6)
pTyr869 (6)
pTyr1092 (5)
Internal (4)
aa301-350 (4)
aa693-893 (4)
pSer1026 (4)
pSer1071 (4)
pSer695 (4)
pTyr1068 (4)
aa1010-1090 (3)
aa319-484 (3)
aa888-1210 (3)
pTyr1069 (3)
aa1110-1190 (2)
aa1163-1191 (2)
aa1189-1199 (2)
aa25-346 (2)
aa960-1040 (2)
aa985-996 (2)
pSer1045 (2)
pTyr845 (2)
Glu687 (1)
His672 (1)
Phe1065 (1)
Pro1019 (1)
Ser1104 (1)
Ser1166 (1)
Thr1191 (1)
Thr654 (1)
Thr669 (1)
Thr693 (1)
Tyr1016 (1)
Tyr1197 (1)
Val1010 (1)
aa1010-1029 (1)
aa1015-1064 (1)
aa1030-1110 (1)
aa1031-1080 (1)
aa1036-1085 (1)
aa1041-1090 (1)
aa1050-1130 (1)
aa1061-1110 (1)
aa1077-1126 (1)
aa1100-1150 (1)
aa1116-1130 (1)
aa1120-1200 (1)
aa1126-1175 (1)
aa1139-1188 (1)
aa1161-1210 (1)
aa1165-1185 (1)
aa1165-1186 (1)
aa1166-1180 (1)
aa1195-1199 (1)
aa25-249 (1)
aa27-57 (1)
aa620-700 (1)
aa630-710 (1)
aa651-700 (1)
aa661-710 (1)
aa810-890 (1)
aa836-885 (1)
aa940-1020 (1)
aa966-1015 (1)
aa970-1019 (1)
aa986-1035 (1)
aa991-1040 (1)
pTyr1173 (1)
pTyr992 (1)
pTyr998 (1)
Publications
No (569)
Yes (2)
Showing 1-25 out of 571 results
Anti-EGFR Antibody IHC-plus™ LS-A9399

Rabbit Polyclonal to Human EGFR
Human
IHC-P
Unconjugated
Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2199

Sheep Polyclonal (IgG) to Human EGFR
Chicken, Mouse, Rat, Human
ELISA ICC IF IHC-P IP WB
Unconjugated
Anti-EGFR Antibody (Internal) IHC-plus™ LS-B2914

Sheep Polyclonal to Human EGFR
Chicken, Mouse, Rat, Human
ICC IHC-P IP WB
Unconjugated
Anti-EGFR Antibody (aa27-57) LS-C100292

Rabbit Polyclonal to Human EGFR
Human
IHC-P WB
Unconjugated
Anti-EGFR Antibody (clone H11) LS-C26773

Mouse Monoclonal [clone H11] (IgG1)
Human
Flo IF IHC-P IP
Unconjugated
Anti-EGFR Antibody (clone 528, Azide-free) LS-C87999

Mouse Monoclonal [clone 528] (IgG2a) to Human EGFR
Dog, Human
Block Flo Inhb IP
Unconjugated, Azide-free
Anti-EGFR Antibody (clone 111.6) LS-C88139

Mouse Monoclonal [clone 111.6] (IgG1) to Human EGFR
Human
IHC-P IP WB
Unconjugated
Anti-EGFR Antibody (clone 111.6, Biotin) LS-C88140

Mouse Monoclonal [clone 111.6] (IgG1) to Human EGFR
Human
Block IHC-P IP WB
Biotin Conjugated
Anti-EGFR Antibody (clone 225) LS-C88000

Mouse Monoclonal [clone 225] (IgG1) to Human EGFR
Human, Monkey
Block IP
Unconjugated
Anti-EGFR Antibody (clone 225, Azide-free) LS-C88001

Mouse Monoclonal [clone 225] (IgG1) to Human EGFR
Human, Monkey
Block Inhb IP
Unconjugated, Azide-free
Anti-EGFR Antibody (Extracellular Domain, FITC) LS-C43911

Rat Monoclonal (IgG2a) to Human EGFR
Human
Flo
FITC Conjugated
Anti-EGFR Antibody (phospho-Tyr1068) LS-C6640

Rabbit Polyclonal (IgG) to Human EGFR
Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-EGFR Antibody (aa1166-1180) IHC-plus™ LS-B648

Rabbit Polyclonal to Human EGFR
Mouse, Rat, Human
ELISA IHC-P IP WB
Unconjugated
Anti-EGFR Antibody (clone H11, Azide-free) LS-C88072

Mouse Monoclonal [clone H11] (IgG1,k) to Human EGFR
Human
Flo IF IHC-P IP WB
Unconjugated, Azide-free
Anti-EGFR Antibody (clone 111.6, Azide-free) LS-C88141

Mouse Monoclonal [clone 111.6] (IgG1) to Human EGFR
Human
Block IHC-P IP WB
Unconjugated, Azide-free
Anti-EGFR Antibody (clone H11) IHC-plus™ LS-B5166

Mouse Monoclonal [clone H11] (IgG1,k) to Human EGFR
Human
Flo IF IHC-P IP WB
Unconjugated
Anti-EGFR Antibody (clone 528) LS-C87997

Mouse Monoclonal [clone 528] (IgG2a) to Human EGFR
Dog, Human
Block Flo IP
Unconjugated
Anti-EGFR Antibody (clone 528, Biotin) LS-C87998

Mouse Monoclonal [clone 528] (IgG2a) to Human EGFR
Dog, Human
Block Flo IP
Biotin Conjugated
Anti-EGFR Antibody (clone 31G7) LS-C312049

Mouse Monoclonal [clone 31G7] (IgG1) to Human EGFR
Human
IHC-Fr IHC-P
Unconjugated
Anti-EGFR Antibody (aa986-1035) LS-C117640

Rabbit Polyclonal (IgG) to Human EGFR
Mouse, Rat, Human
ELISA IF IHC-P WB
Unconjugated
Anti-EGFR Antibody (aa1004-1033, APC) LS-C213690

Rabbit Polyclonal (IgG) to Human EGFR
Human
ELISA Flo IHC WB
APC Conjugated
Anti-EGFR Antibody (Extracellular Domain, clone 423103) LS-C65402

Rat Monoclonal [clone 423103] (IgG2a) to Human EGFR
Human
ELISA Flo
Unconjugated
Anti-EGFR Antibody (Extracellular Domain, clone ICR10) LS-C43910

Rat Monoclonal [clone ICR10] (IgG2a) to Human EGFR
Human
Flo IHC-Fr IP
Unconjugated
Anti-EGFR Antibody (clone EGFR.1, Biotin) LS-C88063

Mouse Monoclonal [clone EGFR.1] (IgG2b,k) to Human EGFR
Horse, Human
Flo
Biotin Conjugated
Anti-EGFR Antibody LS-C497697

Rabbit Monoclonal (IgG) to Human EGFR
Mouse, Human
ICC IF IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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