EFNA5 / Ephrin A5

ephrin-A5

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

EFNA5 / Ephrin A5 (10)

Publications

No (10)

Tag

6His, C-terminus (2)

Fc, C-terminus (2)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (2)

Rat (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Human Cells (2)

Mammalian Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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Human EFNA5 / Ephrin A5 Protein (Recombinant His-T7) (aa21-203) - LS-G25414

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.7 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Mouse EFNA5 / Ephrin A5 Protein (Recombinant 6His, C-terminus) (Gln21-Gln206) - LS-G139251

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.5 kDa

Price:

10 µg/$281; 50 µg/$389

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EFNA5 / Ephrin A5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118277

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.3 kDa

Price:

100 µg/$494

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Rat EFNA5 / Ephrin A5 Protein (Recombinant His) (aa21-203) - LS-G20691

Source:

E. coli

Tag:

His

Molecular Weight:

25.3 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat EFNA5 / Ephrin A5 Protein (Recombinant His) (aa21-203) - LS-G22899

Source:

Yeast

Tag:

His

Molecular Weight:

23.2 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human EFNA5 / Ephrin A5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75753

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.3 kDa

Price:

20 µg/$150

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Human EFNA5 / Ephrin A5 Protein (Recombinant GST, N-terminus) (aa114-203) - LS-G58417

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EFNA5 / Ephrin A5 Protein (Recombinant Fc, C-terminus) (Gln21-Asn203) - LS-G139569

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human EFNA5 / Ephrin A5 Protein (Recombinant Fc, C-terminus) (Gln21-Asn203) - LS-G40034

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Mouse EFNA5 / Ephrin A5 Protein (Recombinant 6His, C-terminus) (Gln21-Gln206) - LS-G39460

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.5kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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