EFNA1 / Ephrin A1

ephrin-A1

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

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Products

Proteins (20)

Type

Over-Expression Lysate (4)

Recombinant (16)

Target

EFNA1 / Ephrin A1 (20)

Publications

No (20)

Tag

6His, C-terminus (2)

Fc, C-terminus (3)

Fc/6His,C-terminus (1)

Fc-6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (3)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (13)

Mouse (3)

Rat (2)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (3)

Human Cells (3)

Mammalian Cells (5)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (8)

Biologically Active

Biologically active (2)

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Mouse EFNA1 / Ephrin A1 Protein (Recombinant Fc-6His, C-terminus) - LS-G136826

Source:

Mammalian Cells

Tag:

Fc-6His, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.3 kDa

Price:

50 µg/$279; 10 µg/$235; 1 mg/$952; 500 µg/$715

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Mouse EFNA1 / Ephrin A1 Protein (Recombinant Fc/6His,C-terminus) (Asp19-Ser182) - LS-G138554

Source:

Mammalian Cells

Tag:

Fc/6His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.3 kDa

Price:

10 µg/$229; 50 µg/$262

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EFNA1 / Ephrin A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104212

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.3 kDa

Price:

100 µg/$494

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Human EFNA1 / Ephrin A1 Protein (Recombinant His-SUMO) (aa19-182) - LS-G20688

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

35.34 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat EFNA1 / Ephrin A1 Protein (Recombinant His) (aa18-182) - LS-G20689

Source:

E. coli

Tag:

His

Molecular Weight:

23.5 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human EFNA1 / Ephrin A1 Protein (Recombinant His-T7) (aa19-182) - LS-G25412

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Rat EFNA1 / Ephrin A1 Protein (Recombinant His) (aa18-182) - LS-G22898

Source:

Yeast

Tag:

His

Molecular Weight:

21.4 kD

Price:

1 mg/$1,683; 100 µg/$499; 20 µg/$364

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Human EFNA1 / Ephrin A1 Protein (Recombinant GST) (Full Length) - LS-G28306

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

50.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human EFNA1 / Ephrin A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75749

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.79 kDa

Price:

20 µg/$150

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Human EFNA1 / Ephrin A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75750

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.3 kDa

Price:

20 µg/$150

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Human EFNA1 / Ephrin A1 Protein (Recombinant GST, N-terminus) (aa21-130) - LS-G58414

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EFNA1 / Ephrin A1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65532

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.8 kDa

Price:

20 µg/$1,107

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EFNA1 / Ephrin A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100292

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.79 kDa

Price:

100 µg/$494

Select

Human EFNA1 / Ephrin A1 Protein (Recombinant His) - LS-G1500

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human EFNA1 / Ephrin A1 Protein (Recombinant Fc, C-terminus) (Full Length) - LS-G136819

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5 kDa

Price:

50 µg/$453; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987

Select

Human EFNA1 / Ephrin A1 Protein (Recombinant Fc, C-terminus) (Asp19-Ser182) - LS-G139078

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5 kDa

Price:

10 µg/$281; 50 µg/$389

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Human EFNA1 / Ephrin A1 Protein (Recombinant 6His, C-terminus) (Asp19-Ser182) - LS-G139568

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.4 kDa

Price:

10 µg/$288; 50 µg/$436

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Human EFNA1 / Ephrin A1 Protein (Recombinant 6His, C-terminus) (Asp19-Ser182) - LS-G39328

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.39kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

Select

Human EFNA1 / Ephrin A1 Protein (Recombinant Fc, C-terminus) (Asp19-Ser182) - LS-G39498

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

46.5kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

Select

Mouse EFNA1 / Ephrin A1 Protein (Recombinant Fc-6His, C-terminus) (Asp19-Ser182) - LS-G39508

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.3kD

Price:

10 µg/$229; 50 µg/$262; 500 µg/$544; 1 mg/$725

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