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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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EEF1E1 / AIMP3
eukaryotic translation elongation factor 1 epsilon 1
EEF1E1 / AIMP3 is a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
| Gene Name: | eukaryotic translation elongation factor 1 epsilon 1 |
| Synonyms: | EEF1E1, AIMP3, Elongation factor p18, p18 |
| Target Sequences: | NM_004280 NP_004271.1 O43324 |
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