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EDF1 / MBF1

endothelial differentiation-related factor 1

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

Gene Name:	endothelial differentiation-related factor 1
Synonyms:	EDF1, EDF-1, Multiprotein bridging factor 1, Multiprotein-bridging factor 1, MBF1
Target Sequences:	AJ005259 NP_003783.1 O60869

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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