ECSIT

ECSIT signalling integrator

Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

ECSIT (7)

Publications

No (7)

Tag

GST (2)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human ECSIT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87788

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$150

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Human ECSIT Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70707

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$1,107

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Human ECSIT Protein (Recombinant GST) (Full Length) - LS-G33709

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.84 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ECSIT Protein (Recombinant GST) (Full Length) - LS-G33711

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.93 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ECSIT Protein (Recombinant His, N-Terminal) - LS-G144681

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

49 kDa

Price:

50 µg/$419

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ECSIT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125949

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

100 µg/$494

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Human ECSIT Protein (Recombinant His) - LS-G1964

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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