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EBI3 / IL-27B
Epstein-Barr virus induced 3
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
| Gene Name: | Epstein-Barr virus induced 3 |
| Synonyms: | EBI3, Epstein-Barr virus induced 3, IL-27 subunit beta, IL27 subunit, IL27B, Interleukin-27 subunit beta, IL-27B, Cytokine receptor, EBV-induced gene 3 protein, IL35 subunit |
| Target Sequences: | NM_005755 NP_005746.2 Q14213 |
Publications (2)
1
IL-35 mitigates murine acute graft-versus-host disease with retention of graft-versus-leukemia effects. Liu Y, Wu Y, Wang Y, Cai Y, Hu B, Bao G, Fang H, Zhao L, Ma S, Cheng Q, Song Y, Liu Y, Zhu Z, Chang H, Yu X, Sun A, Zhang Y, Vignali DA, Wu D, Liu H. Leukemia. 2015 29:939-46. (IHC; Mouse)
[Full Text Article]
[PubMed:25363669]
[PMC:PMC4391991]
Related Antibodies: LS-B5764.
2
Human neutrophils activated by TLR8 agonists, with or without IFN?, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39. Marco A Cassatella, Elisa Gardiman, Fabio Arruda-Silva, Francisco Bianchetto-Aguilera, Sara Gasperini, Mattia Bugatti, William Vermi, Frederique Larousserie, Odile Devergne, Nicola Tamassia. Journal of leukocyte biology. 2020 November;108:1515-1526. [Full Text Article]
[PubMed:32480433]
Related Antibodies: LS-C314301.
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EBI3 / IL-27B Rat anti-Mouse Monoclonal (DNT27) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
EBI3 / IL-27B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
EBI3 / IL-27B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
EBI3 / IL-27B Mouse anti-Human Monoclonal (aa21-229) Antibody
Human
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296
EBI3 / IL-27B Rabbit anti-Mouse Polyclonal (aa200-230) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
100 µg/$386
EBI3 / IL-27B Mouse anti-Human Monoclonal (aa129-229) Antibody
Human
ELISA
Unconjugated
100 µg/$705
EBI3 / IL-27B Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
100 µl/$904
EBI3 / IL-27B Rat anti-Mouse Monoclonal (10J803) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$386
EBI3 / IL-27B Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
EBI3 / IL-27B Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
EBI3 / IL-27B Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
EBI3 / IL-27B Rabbit anti-Human Polyclonal (aa21-229) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
EBI3 / IL-27B Rat anti-Mouse Monoclonal (5P6G8) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$386
E. coli
His
24.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
Wheat Germ Extract
GST
50.71 kDa
2 µg/$439
Fast Shipping
EBI3 / IL-27B Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
EBI3 / IL-27B Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
EBI3 / IL-27B Mouse anti-Human Monoclonal (15k8D10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
EBI3 / IL-27B Rat anti-Mouse Monoclonal (IMG10J706) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$386
EBI3 / IL-27B Rat anti-Mouse Monoclonal (IMG10J763) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$386
EBI3 / IL-27B Rat anti-Mouse Monoclonal (IMG5P10D3) Antibody
Mouse
Flo, WB
Unconjugated
100 µg/$386
EBI3 / IL-27B Mouse anti-Human Monoclonal (42N1G4) Antibody
Human
Flo, WB
Unconjugated
0.1 mg/$386
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