EAR2 / NR2F6

nuclear receptor subfamily 2, group F, member 6

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

EAR2 / NR2F6 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human EAR2 / NR2F6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67308

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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Human EAR2 / NR2F6 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G64648

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

25 µg/$670; 10 µg/$479

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Human EAR2 / NR2F6 Protein (Recombinant GST, N-terminus) (aa273-351) - LS-G58474

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human EAR2 / NR2F6 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-404) - LS-G56429

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human EAR2 / NR2F6 Protein (Recombinant 6His, N-terminus) (aa1-404) - LS-G57050

Source:

Mammalian Cells

Tag:

6His, N-terminus

Price:

100 µg/$1,116; 20 µg/$461; 1 mg/$3,921

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Human EAR2 / NR2F6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79517

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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EAR2 / NR2F6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100488

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

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