E6AP / UBE3A

ubiquitin protein ligase E3A

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

E6AP / UBE3A (12)

Publications

No (12)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (3)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Mammalian Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

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Human E6AP / UBE3A Protein (Recombinant His, N-Terminal) (Ser158-Leu407) - LS-G13311

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Mouse E6AP / UBE3A Protein (Recombinant 6His, N-terminus) (aa547-875) - LS-G57277

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human E6AP / UBE3A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65491

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.9 kDa

Price:

20 µg/$1,107

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Human E6AP / UBE3A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65492

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.5 kDa

Price:

20 µg/$1,107

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Human E6AP / UBE3A Protein (Recombinant GST, N-terminus) (aa51-150) - LS-G60468

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse E6AP / UBE3A Protein (Recombinant 6His, N-terminus) (aa542-870) - LS-G56615

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Mouse E6AP / UBE3A Protein (Recombinant DDK,C-terminus) (aa542-870) - LS-G57064

Source:

Mammalian Cells

Tag:

DDK,C-terminus

Price:

100 µg/$1,009; 20 µg/$431; 1 mg/$3,451

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Human E6AP / UBE3A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75670

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.1 kDa

Price:

20 µg/$150

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Human E6AP / UBE3A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75669

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.5 kDa

Price:

20 µg/$215

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Human E6AP / UBE3A Protein (Recombinant GST) (Full Length) - LS-G30828

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

127.1 kDa

Price:

10 µg/$479; 25 µg/$670

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E6AP / UBE3A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107598

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.1 kDa

Price:

100 µg/$494

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E6AP / UBE3A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.5 kDa

Price:

100 µg/$710

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